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The DNA, RNA, and Histone Methylomes free ebook download

Category:
Medicine

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Catalogue

Author(s):	Stefan Jurga

Date:	2019	Format:	PDF,EPUB	Language:	English	ISBN/ASIN:	3030147916
Pages:	1	OCR:		Quality:		ISBN13:
Uploader:	eternal	Upload Date:	8/29/2019 3:30:52 PM

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This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.
Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.

This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
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	Title	Link	Password	Size (MB)	Thank to	Inform Admin
2574032	Book	http://tezfiles.com/file/ea747c389a012...		42.89	eternal

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The DNA, RNA, and Histone Methylomes free ebook download

Category: Medicine

Description: Click to see full description

Category:
Medicine